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KMID : 0363420170310010043
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Journal of Korean Oriental Pediatrics
2017 Volume.31 No. 1 p.43 ~ p.51
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The Effect of Douchi Hataedock Treatment for Dermatophagoides Farinae-Induced Atopic Dermatitis-like Skin Lesions by Controlling IL-4 Activity
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Ahn Sang-Hyun
Kim Jae-Kyu
Cheon Jin-Hong
Kim Ki-Bong
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Abstract
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Objectives: Hataedock method is a Korean medical therapy which removes fetal toxin by orally administering herbal
decoction to neonates. This study was to observe skin damage and anti-inflammatory effect via regulating IL-4 activity in NC/Nga mice which were induced atopic dermatitis (AD)-like skin lesion by Dermatophagoides (D.) farinae after applying Douchi Hataedock method.
Methods: NC/Nga mice with 3 weeks of gestational age were used. Each 10 mice were allocated to the control group
(Ctrl), the AD-induced group (AE), and the group which induced AD after administering Douchi extract (GT). After 4 weeks from administering Douchi extract to the mice, the primary AD was induced by applying D. farinae extract 6 times per week for 3 weeks and then the secondary AD was induced by the same method after 1 week from the primary AD induction. To identify the skin damage and anti-inflammatory effect, we observed LxR, IL-4, Fc ε receptor, substance P, and NF-κB.
Results: The GT group showed alleviation of skin injury and decrease in capillary angiogenesis. Stratum corneum damage, epithelial cell hyperplasia, lymphocyte infiltration, and capillary distribution relatively decreased in the GT group.
LxR-positive reaction in the GT group were increased by 53% than that of the AE group. IL-4 production, Fc ε receptor activity, and substance P-positive reaction in the GT group were decreased by 82%, 42%, and 82% respectively compare to those of the AE group. NF-κB-positive reaction in the GT group were decreased by 15% compare to that of the AE group.
Conclusions: Hataedock method with Douchi extract alleviated AD via reducing inflammatory cytokines secreted at the early stage of AD. Thus, Douchi Hataedock method has a beneficial effect for the prevention and treatment of AD.
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KEYWORD
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Hataedock, Douchi, Atopic dermatitis, IL-4, Fc ε recetor, Substance P, NF-k
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